Today is 17.8.2018
The time is 19:46

Dr. Encho Stoyanov

specialist in sports medicine


Autologous Platelet Rich Plasma Therapy

What is Autologous Platelet Rich Plasma Therapy?

Autologous Platelet Rich Plasma Therapy (A-PRP) is a promising solution to accelerate healing naturally without subjecting patients to significant risk. The philosophy is to merge cutting edge technology with the body’s natural ability to heal. PRP technology was initially developed 20 years ago to aide with wound healing and blood loss. Its benefits are now being applied towards the facilitation of healing tendons, cartilage, muscles, bone, scars, corneal wounds and chronic wounds. In fact, A-PRP has been widely used for years in Europe and the USA to treat various sports injuries

What is the plasma like?

Plasma contains many factors essential for cell survival such as nutriments, vitamins, hormones, electrolytes and proteins. Among the plasma proteins, there are the essential molecules for the coagulation process and generation of the fibrin polymer that will serve as a scaffold for cell migration, differentiation and proliferation.

A-PRP is also used in combination with freshly extracted cells (bone marrow, adipose tissue, skin cells, etc.) Platelets are the key are key actors of hard and soft tissue repair mechanisms. They provide the essential growth factors (FGF, PDGF, TGF-ß , EGF, VEGF, IGF) involved in:

  • Stem cell migration, differentiation and proliferation.
  • Stimulation of cells such as fibroblasts and endothelial cells, to induce new extracellular matrix deposition and neo-vascularization.


  • Formation of tridimensional fibrin network.
  • Release of chemo-attractants by leukocytes and platelets present in the network
  • Migration of macrophages and stem cells
  • Stem cell proliferation
  • Stem cell differentiation into different cell types needed for tissue restoration

Key factors

  • Autologous therefore non immunogenic
  • Release of the main growth factors involved in tissue repair and regeneration
  • Reduced risk of infections
  • Improvement of microvascularization
  • Stimulation of mesenchymal stem cells
  • Stimulation of fibroblasts growth and collagen production
  • Acceleration of healing process, reduction of pain and of hospitalization time

How does a A-PRP Procedure Work?
Using the patient’s own blood, specially prepared platelet are taken and then re-injected into the affected area. These platelets release substances known as “growth factors” that lead to tissue healing. For example, when you cut yourself, the body’s natural response is to attract platelets that release growth factors and facilitate the healing. By concentrating the platelets we increase the release of growth factors, which promotes healing.

The human body has a remarkable ability to heal itself and by re-injecting concentrated platelets we are facilitating the natural healing process.

What are the Benefits of A-PRP Treatment?
Patients can expect to see significant improvement in symptoms; elimination of need for more traditional treatments such as medications, cortisone inceptions or surgery; and a dramatic return of function.

How Soon can I Go Back to Regular Physical Activity?
This treatment is not “quick fix” and is designed to promote long-term healing. The process of A-PRP requires time and rehabilitation. Patients who follow a course of physical therapy are likely to see the most improvement in the affected area. A-PRP accelerates and shortens the recovery process in chronic injuries and new acute injuries.

How do I Prepare for an Injection?
Patients should schedule an evaluation to determine if A-PRP is a viable treatment option.
The A-PRP injection is preformed on an outpatient basis. Do not take anti-inflammatories one week before or after the injection as this may limit the treatment benefits.
Depending on a patient’s condition, a series of 1-3 injections may be required.

How Do I Care of the Injection Site After Treatment?
Initially the procedure may cause some localized soreness and discomfort.


CELLULAR MATRIX is a synergistic association of autologous Platelet Rich Plasma and Hyaluronic Acid. It is prepared extemporaneously in a single step in a sterile, closed system.

For the treatment of OA, Cellular Matrix combines the pain and mobility improvements of HA biopolymer with the stimulation properties of growth factors provided by PRP an autologous blood-derived product. Indeed, while the hyaluronic acid restores the viscoelastic properties of the synovial fluid in the osteoarthritic joints, A-PRP stimulates the surrounding cells, for tissue repair.